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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 7

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 7 of 11
TomFromTexas
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Jun 4, 2025 at 7:38 AM#31
josh_phd_bmore said:
One practical note: write down what you did and when, before you need it.

Bookmarking. The distinction being drawn above is the one nobody else makes. Sending this to two other people who asked me the same thing last week.

13 11PharmD_Rodriguez, julia.endo, JessicaM_2024 and 10 others
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claudia_zurich
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Jun 17, 2025 at 2:38 PM#32

Clinical perspective, offered as context rather than as advice. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

14 12tammy_FL, Dr.LipidDallas, alex_tucson and 11 others
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JennaRN
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Jun 30, 2025 at 9:30 PM#33
claudia_zurich said:
It helps to ask what evidence would change your mind before you look at any.

Mine went the same way, slower. I had assumed I was the exception until I read this.

15 13BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 12 others
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dan_philly
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Jul 14, 2025 at 4:14 AM#34
claudia_zurich said:
It helps to ask what evidence would change your mind before you look at any.

There is a second half to this that has not been said yet. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

16 14Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 13 others
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lucas_SP_BR
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Jul 27, 2025 at 10:51 AM#35

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

That is the short version; the long version is somebody else's post.

17 15tampaLisa73, KarenAZ_mom, zoe_NC and 14 others
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