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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 8

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 8 of 11
ricardo_MIA
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Aug 9, 2025 at 5:20 PM#36

Following on from claudia_zurich — and this may be the naive question:

How would you tell the difference between that and the alternative explanation?

Last edited: Aug 9, 2025 at 10:20 PM
18 16JakeSmashed95, NauseaFreeNow, SteveThurs and 15 others
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MASHdoc_SA
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Aug 22, 2025 at 11:41 PM#37
lucas_SP_BR said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

I read this differently from lucas_SP_BR, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

19 17TrialTracker_MD, JennaRN, LabKate and 16 others
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SandraNC_45
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Sep 5, 2025 at 5:55 AM#38
lucas_SP_BR said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

20 18NicoleRaleigh, james_edin, FranDenver and 17 others
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Dr.GutHealth
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Sep 18, 2025 at 12:01 PM#39
lucas_SP_BR said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

Last edited: Sep 18, 2025 at 5:01 PM
21 19Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 18 others
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TrialTracker_MD
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Oct 1, 2025 at 5:59 PM#40

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

43 16lori_vegas, Dr.PulmRoch, maya_sedona and 40 others
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