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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 9

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 9 of 11
mike_mealprep
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Oct 14, 2025 at 9:09 PM#41
TrialTracker_MD said:
It is worth asking what the claim would look like if it were false.

Same pattern here, and in the same order. Posting only so the count is not one.

Last edited: Oct 15, 2025 at 3:09 AM
44 17mia_MS2, LeilaHI, marcus_mpls and 41 others
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SleepDoc_PDX
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Oct 28, 2025 at 12:12 AM#42
TrialTracker_MD said:
It is worth asking what the claim would look like if it were false.

Coming at TrialTracker_MD’s question from a different direction. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Correct me if the detail matters more than I have assumed.

45 18hank_denver, carlos_SATX, sophie_paris and 42 others
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Admin
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Nov 10, 2025 at 3:07 AM#43

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.

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Dr.KarenChen
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Nov 23, 2025 at 5:54 AM#44

Following on from TrialTracker_MD — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

47 20mike.trainer_LA, sarah_nash92, FitDadDave and 44 others
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NauseaFreeNow
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Dec 6, 2025 at 8:34 AM#45
SleepDoc_PDX said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

48 21cory_ATX, lori_vegas, Dr.PulmRoch and 45 others
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