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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 11

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 11 of 11
DataDave
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Feb 22, 2026 at 7:15 PM#51

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

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pete_manc_UK
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Mar 7, 2026 at 6:23 PM#52

A narrower follow-up, since the general answer is now clear:

How long did you give it before you decided it was working?

Last edited: Mar 8, 2026 at 12:23 AM
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FitDadDave
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Mar 20, 2026 at 5:24 PM#53
DataDave said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

This is where I part company with the consensus forming above. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

Last edited: Mar 20, 2026 at 8:24 PM
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Dr.EndoEP
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Apr 2, 2026 at 4:17 PM#54
DataDave said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

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hans_munich
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Apr 15, 2026 at 3:03 PM#55

Old thread, but it comes up first when you search for this, so it is worth updating. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Last edited: Apr 15, 2026 at 9:03 PM
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