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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 5

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 5 of 11
adam_van
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Jan 21, 2025 at 2:09 AM#21
bri_stats said:
Say what you would expect to see if you were wrong, before you look.

Pushing back on bri_stats here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

32 5FranDenver, Dr.BariatricHTX, LindaRN_retired and 29 others
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NurseAsh_DET
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Sep 2024
Detroit, MI
Feb 3, 2025 at 1:09 PM#22
bri_stats said:
Say what you would expect to see if you were wrong, before you look.

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

33 6ricardo_MIA, BrianDallas92, labquiet_amy and 30 others
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steph_laguna
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Nov 2024
Laguna Beach, CA
Feb 17, 2025 at 12:01 AM#23
bri_stats said:
Say what you would expect to see if you were wrong, before you look.

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

34 7carl_compliance, DanielChem_CHI, marco_milano and 31 others
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claudia_zurich
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Zurich, CH
Mar 2, 2025 at 10:46 AM#24

From the other side of the consultation, briefly. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

35 8alex_tucson, kevin_tulsa, Dr.PainCLE and 32 others
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DoseLogDan
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Feb 2025
Montana
Mar 15, 2025 at 9:23 PM#25
claudia_zurich said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

This is my experience too, for whatever a second data point is worth.

36 9carlos_SATX, sophie_paris, mel_PDX and 33 others
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