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ForumsTirzepatide (Mounjaro / Zepbound)Tirzepatide and cholesterol — March 2026 Page 5

Tirzepatide and cholesterol — March 2026

paige_pharma Tue, Dec 16, 2025 at 4:18 AM 37 replies 1,549 viewsPage 5 of 8
newstart_MO
New Member
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Feb 2026
Springfield, MO
Dec 18, 2025 at 8:09 AM#21
MikeFit_NJ said:
That holds where the measurement is reliable.

Mine went the same way, slower. The detail I would add is minor and it is already implied above.

Last edited: Dec 18, 2025 at 2:09 PM
6 6bri_stats, pete_manc_UK, anna.melb_AU and 3 others
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carl_compliance
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Nov 2024
Raleigh, NC
Dec 18, 2025 at 9:58 PM#22
MikeFit_NJ said:
That holds where the measurement is reliable.

Coming at MikeFit_NJ’s question from a different direction. SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1. Different trials, different populations, so the comparison is indicative rather than decisive — but SURPASS-2 was a genuine head-to-head and it pointed the same way.

Last edited: Dec 19, 2025 at 12:58 AM
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LabKate
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Dec 19, 2025 at 11:47 AM#23

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

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hans_munich
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Dec 20, 2025 at 1:37 AM#24

One thing that is still open after MikeFit_NJ’s answer:

Whether anyone has held 10mg long term rather than climbing, and what happened over the following year?

3 3tammy_FL, Dr.LipidDallas, alex_tucson
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tampaLisa73
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Oct 2024
Tampa, FL
Dec 20, 2025 at 3:27 PM#25
LabKate said:
Keep the original post as written when you update it, and add the correction underneath.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

2 2TomFromTexas, mike.trainer_LA
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