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ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 7

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 7 of 10
pete_nash
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Jul 26, 2024 at 6:13 PM#31
wendy_avl said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

This is exactly what I could not find anywhere else. Adding it to my notes with a link back to this thread.

23 21Admin, Dr.Martinez, mike_mod and 20 others
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NurseLeah_Nash
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Jul 27, 2024 at 1:36 AM#32

Clinical perspective, offered as context rather than as advice. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

24 22BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 21 others
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KevinCompounds
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Jul 27, 2024 at 8:59 AM#33
NurseLeah_Nash said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Same experience, arrived at from the opposite direction.

25 23MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 22 others
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jason_sac26
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Jul 27, 2024 at 4:22 PM#34
NurseLeah_Nash said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

There is a second half to this that has not been said yet. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

Last edited: Jul 27, 2024 at 6:22 PM
26 24maya_sedona, stefan_berlin, Dr.EM_Chicago and 23 others
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VendorMark
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Jul 27, 2024 at 11:44 PM#35

The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

27 0claudia_zurich, nancy_portland, rick_sfbay and 24 others
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