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ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 10

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 10 of 10
SandraNC_45
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Jul 31, 2024 at 8:17 AM#46
zoe_NC said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

9 7FranDenver, Dr.BariatricHTX, LindaRN_retired and 6 others
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nancy_portland
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Jul 31, 2024 at 3:34 PM#47

Old thread, but it comes up first when you search for this, so it is worth updating. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

10 8KristenIndy, MarkLI_maint, Dr.PeteFamMed and 7 others
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Dr.EM_Chicago
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Jul 31, 2024 at 10:50 PM#48

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Last edited: Aug 1, 2024 at 2:50 AM
11 9Dr.ReproEndo, lucas_SP_BR, lisa_labSD and 8 others
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tommy_boulder
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Aug 1, 2024 at 6:06 AM#49
Dr.EM_Chicago said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

This is my experience too, for whatever a second data point is worth. Nothing to add that would improve it.

Last edited: Aug 1, 2024 at 7:06 AM
12 10dan_philly, MeganSA_TX, LarryQC_SD and 9 others
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sophie_paris
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Aug 1, 2024 at 1:22 PM#50
Dr.EM_Chicago said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

There is a second half to this that has not been said yet. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

34 7BethLabQueen, ChrisMacros, KetoKyle and 31 others
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