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ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 8

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 8 of 10
Dr.RaviCardio
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Jul 28, 2024 at 7:06 AM#36

A narrower follow-up, since the general answer is now clear:

What did you change at the same time, and can you separate the two now?

28 1pete_manc_UK, anna.melb_AU, mark_tokyo and 25 others
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InsuranceTom
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Jul 28, 2024 at 2:28 PM#37
VendorMark said:
Say what you would expect to see if you were wrong, before you look.

Pushing back on VendorMark here. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

29 2lucas_SP_BR, lisa_labSD, adam_van and 26 others
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ricardo_MIA
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Jul 28, 2024 at 9:50 PM#38
VendorMark said:
Say what you would expect to see if you were wrong, before you look.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

Last edited: Jul 29, 2024 at 2:50 AM
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fiona_VT
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Jul 29, 2024 at 5:12 AM#39
VendorMark said:
Say what you would expect to see if you were wrong, before you look.

This answered a question I did not know how to ask. Sending this to two other people who asked me the same thing last week.

Last edited: Jul 29, 2024 at 6:12 AM
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Dr.RenalNash
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Jul 29, 2024 at 12:34 PM#40

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Last edited: Jul 29, 2024 at 5:34 PM
3 1maria_elpaso, anders_CPH, Dr.NutriCornell
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