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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 5

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 5 of 10
Dr.PainCLE
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Jul 23, 2024 at 3:41 PM#21
Dr.GutHealth said:
Keep the original post as written when you update it, and add the correction underneath.

This is where I part company with the consensus forming above. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

42 15Dr.PathRoch, mona_PHX, andrew_nyc and 39 others
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mike_nyc
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Jul 23, 2024 at 11:09 PM#22
Dr.GutHealth said:
Keep the original post as written when you update it, and add the correction underneath.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

43 16stefan_berlin, Dr.EM_Chicago, pete_RVA and 40 others
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paige_pharma
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Jul 24, 2024 at 6:37 AM#23
Dr.GutHealth said:
Keep the original post as written when you update it, and add the correction underneath.

Bookmarking. The distinction being drawn above is the one nobody else makes.

Last edited: Jul 24, 2024 at 7:37 AM
44 17adam_van, Dr.SurgeonPGH, rachel_ABQ and 41 others
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Dr.LeslieOBGYN
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Jul 24, 2024 at 2:05 PM#24

From the other side of the consultation, briefly. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

Last edited: Jul 24, 2024 at 8:05 PM
45 18NicoleRaleigh, james_edin, FranDenver and 42 others
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greg_boulder
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Jul 24, 2024 at 9:33 PM#25
Dr.LeslieOBGYN said:
Worth answering the question that was asked rather than the one behind it.

This matches mine closely enough to be worth saying so out loud.

Last edited: Jul 24, 2024 at 11:33 PM
46 19ben_calgary, patPC_UT, Dr.DermMIA and 43 others
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