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ForumsCOA & Analytical TestingCOA red flag compilation — what worked for you? Page 2

COA red flag compilation — what worked for you?

mike_nyc Thu, Mar 21, 2024 at 10:51 PM 36 replies 2,728 viewsPage 2 of 8
VendorMark
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Mar 22, 2024 at 8:06 AM#6

Adding the numbers, since they settle part of this. The four things to check on any report, in order: does it name your batch, who commissioned it, what method was used, and does it report content as well as purity. A report failing any of those is weak evidence regardless of the percentage on it.

Last edited: Mar 22, 2024 at 10:06 AM
23 18DebRD_ATL, KristenIndy, MarkLI_maint and 20 others
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robert_kc
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Mar 22, 2024 at 11:45 AM#7

Following on from Dr.SportsMedIN — and this may be the naive question:

What a vetting checklist should actually contain, as opposed to a list of things that are easy to fake?

22 17SleepFixSam, PurityPaulOR, MaxMetOK and 19 others
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GenomicsKate
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Mar 22, 2024 at 3:24 PM#8
VendorMark said:
The four things to check on any report, in order: does it name your batch, who commissioned it, what method was used, and does it report content as…

Coming at VendorMark’s question from a different direction. Inter-laboratory variation comes from real methodological differences, not sloppiness: which reference standard was used and how it was itself calibrated, the gradient and column, the detection wavelength, and where the integration baseline was drawn. A percentage point or two between competent labs is expected. What is not expected is a large gap, and the usual explanation there is that one report is not of the batch in your hand.

Last edited: Mar 22, 2024 at 8:24 PM
21 16MarkLI_maint, Dr.PeteFamMed, claudia_zurich and 18 others
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mike_nyc
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Mar 22, 2024 at 7:04 PM#9

OP back with an update, since a thread like this is useless without one.

Went back through my own correspondence with an earlier supplier and the warning signs were all there in the replies, weeks before the quality changed. I was reading the product and not the behaviour.

20 15pete_RVA, CarlaRPh_TPA, steph_laguna and 17 others
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TinaHashiRN
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Mar 23, 2024 at 12:38 PM#10
GenomicsKate said:
Inter-laboratory variation comes from real methodological differences, not sloppiness: which reference standard was used and how it was itself…

Agreed, with a caveat about community reputation: it is a lagging indicator. Reports arrive weeks after orders, so a supplier can look excellent for a month after quality has already changed.

10 8MikeNYC_runner and 7 others
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