Has anyone dealt with moisture content analysis for lyophilized peptides?

FDA_TrackerJim said:

Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

From the other side of the consultation, briefly. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.

anna.melb_AU said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Coming at anna.melb_AU’s question from a different direction. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.