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ForumsCOA & Analytical TestingLC-MS/MS vs HPLC for peptide analysis — November 2025 Page 7

LC-MS/MS vs HPLC for peptide analysis — November 2025

TrialTracker_MD Sat, Apr 26, 2025 at 1:49 PM 39 replies 2,208 viewsPage 7 of 8
maria_elpaso
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May 12, 2025 at 3:53 AM#31
TrialTracker_MD said:
I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

Same experience, arrived at from the opposite direction.

1 24FitDadDave
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HealthEcon_DC
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May 13, 2025 at 6:18 AM#32
TrialTracker_MD said:
I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

Coming at TrialTracker_MD’s question from a different direction. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

2 0JessicaH_TX, KevinCompounds
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quinn_sf
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May 14, 2025 at 8:43 AM#33

One concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

3 1mona_PHX, andrew_nyc, Dr.EndoEP
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Sigma-Aldrich — Research-Grade Standards

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Dr.MetabolicMD
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May 15, 2025 at 11:07 AM#34

One thing that is still open after TrialTracker_MD’s answer:

Was that from a primary source or from a summary of one?

4 2Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 1 other
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jason_sac26
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May 16, 2025 at 1:31 PM#35
quinn_sf said:
Practical: whatever you change, write down the date and the reason.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

5 3Dr.PulmRoch, maya_sedona, stefan_berlin and 2 others
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