Particulate matter testing — 6 month update

Dr.NateNeph said:

They are not contradictory, they measure different things, and this is the single most common misreading of a certificate.

I am more sceptical of certificates as a category than this thread is. The document tells you about a sample somebody chose to send, at a moment in time, and nothing about the vial in your hand. Independent purchase-and-test is a different quality of evidence and everything else is inference.

BrianDallas92 said:

I have a certificate reporting 99.2% purity and 6.1mg content on a vial sold as 5mg, and I cannot work out whether those two numbers are consistent or…

Vendor quality matters when discussing certificates of analysis. I've tested my last 6 batches through Janoshik and purity has ranged from 98.9% to 100.3%. Consistency is key.

For anyone new: always request the COA, and consider independent verification. The $300 for a Janoshik test is worth the peace of mind.

Dr.PeteFamMed said:

I am more sceptical of certificates as a category than this thread is.

I tested my certificates of analysis batch through Janoshik — 97.6% purity. That's within acceptable range for compounded peptides. Turnaround was 14 business days.

The test costs ~$144 but gives you actual HPLC chromatography data plus mass spec confirmation. For the peace of mind alone, it's worth every penny. I test every new batch from a new vendor.

One thing that is still open after MeganSA_TX’s answer:

Why two laboratories report different purity for the same batch, and which number to believe?

Reporting back.

Purity and content being different measurements was the piece I was missing. The vial was overfilled and pure, which is a very different problem from the one I thought I had.