Amylin co-agonism: CagriSema REDEFINE results and implications — 6 month update

pete_nash said:

The pharmacokinetics explain nearly every practical question asked here.

This is exactly what I could not find anywhere else.

Adding the clinical framing, because it changes how the question reads. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

VendorMark said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again.