The figures, for anyone assembling their own picture. Numbers worth memorising for this class: Tmax one to three days for the weekly peptides, terminal half-life about a week for semaglutide and about five days for tirzepatide, steady state at four to five half-lives, subcutaneous bioavailability high enough that site choice is irrelevant.
Following on from pete_nash — and this may be the naive question:
Which effects tachyphylax and which persist, because the answer explains why tolerability improves while the appetite effect keeps working?
PeptideSynthNJ said:Numbers worth memorising for this class: Tmax one to three days for the weekly peptides, terminal half-life about a week for semaglutide and about…
Coming at PeptideSynthNJ’s question from a different direction. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
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View ResultsClosing the loop on my own question.
Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.
VendorMark said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.