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ForumsCardiovascular OutcomesSOUL trial preliminary data — need advice Page 3

SOUL trial preliminary data — need advice

roxy_nash Mon, Mar 23, 2026 at 8:00 PM 11 replies 847 viewsPage 3 of 3
laura_annarbor
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Mar 25, 2026 at 8:09 PM#11
sophie_paris said:
Read four things before the headline number.

Saving this. It is the first explanation that did not require me to already understand it.

Last edited: Mar 25, 2026 at 10:09 PM
6 4labquiet_amy, emily_PDX, Dr.SleepRoch and 3 others
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sean_dublin
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Mar 27, 2026 at 11:59 AM#12

Adding the clinical framing, because it changes how the question reads.

Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational studies can provide useful evidence.

A recent PSM study of 12,000 GLP-1 users vs matched controls showed reduced stroke risk (HR 0.82) over 3 years of follow-up[1].

These results complement the RCT data and suggest the benefits translate to real-world populations.

References:
[1] Registry-based cohort study, pre-print 2024.
7 5sean_dublin, hannah_MT, Dr.SportsMedIN and 4 others
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PharmD_Rodriguez
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Mar 29, 2026 at 3:48 AM#13
Dr.GastroMayo said:
bri_stats said: ...regarding the trial evidence...

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

8 6robert_kc, dan_philly, MeganSA_TX and 5 others
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hank_denver
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Mar 30, 2026 at 7:36 PM#14

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

9 7fiona_VT, denise_HTX, raj_cambridge and 6 others
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mike_mod
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Apr 1, 2026 at 11:23 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. No action needed from anybody.

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