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ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — 6 month update

Muscle protein synthesis rates on GLP-1 — 6 month update

PedsEndoPhilly Wed, Sep 10, 2025 at 9:45 PM 31 replies 1,627 viewsPage 1 of 7
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PedsEndoPhilly
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Sep 10, 2025 at 9:45 PM#1

Read the primary source rather than the write-up and the two do not agree, so here is what is actually in it.

The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

Where I think it is weakest: the completion rate deserves as much attention as the headline, because a large effect among those who finished is a different claim from a large effect among those enrolled.

So the question, as narrowly as I can put it: how people are hitting a protein target on a genuinely suppressed appetite, because volume is the binding constraint rather than willingness. Happy to be told the question itself is wrong.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
24 19sarah_TO, wendy_avl, jason_paloalto and 21 others
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Dr.LipidDallas
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Sep 10, 2025 at 11:33 PM#2
PedsEndoPhilly said:
The RDA is the wrong reference and it is worth understanding why.

No disagreement with PedsEndoPhilly. One condition attached. Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

23 18wei_SG, cory_ATX, lori_vegas and 20 others
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PeptideChemSF
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Sep 11, 2025 at 1:21 AM#3
PedsEndoPhilly said:
The RDA is the wrong reference and it is worth understanding why.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

Happy to go further on any of that.

Last edited: Sep 11, 2025 at 5:21 AM
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james_edin
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Sep 11, 2025 at 3:09 AM#4

Answering the narrow version, because the broad one does not have a single answer. On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie. Isolate powders, Greek yoghurt and cottage cheese, egg whites, lean fish, and tinned tuna all deliver a lot of protein in a small physical volume. Front-load it: appetite is usually least suppressed in the first hours after waking and worst on the day or two after dosing, so get the majority in early in the day and early in the week.

I would rather be corrected than agreed with, if it comes to it.

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raj_cambridge
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Sep 11, 2025 at 1:45 PM#5
Dr.LipidDallas said:
Distribution matters less than total but it is not nothing.

Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution. Hydration status moves the lean compartment by a kilogram or more between scans, so any comparison of scans done at different times of day or different hydration states is noise.

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