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ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — 6 month update Page 3

Muscle protein synthesis rates on GLP-1 — 6 month update

PedsEndoPhilly Wed, Sep 10, 2025 at 9:45 PM 31 replies 1,627 viewsPage 3 of 7
fiona_VT
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Sep 16, 2025 at 3:51 AM#11
james_edin said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

Genuinely useful, thank you. I had the facts and not the framework. Sending this to two other people who asked me the same thing last week.

15 15mark_tokyo, hans_munich, jason_sac26 and 12 others
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SleepDoc_PDX
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Sep 16, 2025 at 8:53 PM#12

Clinical perspective, offered as context rather than as advice.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass266 lbs216 lbs193 lbs
Fat mass96 lbs66 lbs43 lbs
Lean mass149 lbs145 lbs150 lbs
Body fat %43%31%22%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.5g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

Last edited: Sep 16, 2025 at 11:53 PM
14 14hank_denver, carlos_SATX, sophie_paris and 11 others
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Dr.CardioMD
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Sep 17, 2025 at 1:55 PM#13
PharmD_Rodriguez said:
The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think this board over-worries about lean mass. Some lean loss is obligatory — you need less muscle to move a smaller body, and preserving mass you no longer need is not a health outcome. The question is whether strength and function held, and mine did.

13 13tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 10 others
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PeptideSynthNJ
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Sep 18, 2025 at 6:58 AM#14

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: Sep 18, 2025 at 10:58 AM
12 12MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 9 others
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Admin
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Sep 19, 2025 at 12:01 AM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. No action needed from anybody.

11 11PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 8 others
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