🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — 6 month update Page 2

Muscle protein synthesis rates on GLP-1 — 6 month update

PedsEndoPhilly Wed, Sep 10, 2025 at 9:45 PM 31 replies 1,627 viewsPage 2 of 7
PeptideSynthNJ
Member
234
1,234
Aug 2024
Princeton, NJ
Sep 12, 2025 at 12:20 AM#6

Adding the numbers, since they settle part of this. If you are tracking this properly: same scanner, same time of day, same hydration, at least six months apart, and read grip strength or a lift number alongside it. Function is the outcome; the scan is the proxy.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Sep 12, 2025 at 4:20 AM
19 14wanda_boise, NurseAsh_DET, BenResearch_OR and 16 others
Reply Quote Save Share Report
mel_PDX
Member
189
890
Dec 2024
Portland, OR
Sep 12, 2025 at 10:55 AM#7

One thing that is still open after james_edin’s answer:

Whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be?

18 13Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 15 others
Reply Quote Save Share Report
PharmD_Rodriguez
Senior Member
3,456
14,567
Jan 2024
Miami, FL
Sep 12, 2025 at 9:30 PM#8
PeptideSynthNJ said:
If you are tracking this properly: same scanner, same time of day, same hydration, at least six months apart, and read grip strength or a lift number…

There is a second half to this that has not been said yet. The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0 g/kg of reference body weight, and not making the deficit larger than the training can support. Cardio does not protect lean mass and in a deep deficit competes with recovery.

Worth separating that from lean-mass preservation, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

17 12robert_kc, dan_philly, MeganSA_TX and 14 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
PedsEndoPhilly
Member
345
1,890
Jun 2024
Philadelphia, PA
Sep 13, 2025 at 8:05 AM#9

Reporting back.

Reporting back — setting the target on reference weight rather than current weight turned an impossible number into a boring one.

16 11Dr.LeslieOBGYN, MikeNYC_runner and 13 others
Reply Quote Save Share Report
VendorMark
Senior Member
3,456
14,567
Jan 2024
Texas
Online
Sep 15, 2025 at 10:50 AM#10
PharmD_Rodriguez said:
The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0…

True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum. High protein is safe in normal kidneys and is not automatically safe in impaired ones.

16 16claudia_zurich, nancy_portland, rick_sfbay and 13 others
Reply Quote Save Share Report

Similar Threads

SELECT trial 4-year follow-up data released — sustained MACE reduction16 replies
GLP-1 receptor agonists and thyroid C-cell concerns — evidence review19 replies
Is there a ceiling effect for GLP-1-mediated weight loss?20 replies
Comparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide6 replies
My 18-month semaglutide journey — comprehensive data log20 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register