🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHeart failure hospitalization reduction on semaglutide — real-world data Page 2

Heart failure hospitalization reduction on semaglutide — real-world data

Dr.CardioMD Sat, May 23, 2026 at 6:53 AM 18 replies 644 viewsPage 2 of 4
Dr.NateNeph
VIP Member
2,987
16,234
Dec 2023
Houston, TX
May 23, 2026 at 3:25 PM#6

One concrete data point for the thread. For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and subcutaneous bioavailability near 89%. Those four numbers explain most of the questions people ask about timing.

Last edited: May 23, 2026 at 5:25 PM
39 9JakeSmashed95, NauseaFreeNow, SteveThurs and 36 others
Reply Quote Save Share Report
sarah_nash92
Member
712
3,123
Jun 2024
Nashville, TN
May 23, 2026 at 6:47 PM#7

One thing that is still open after Dr.EndoIndy’s answer:

What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?

38 8JakeSmashed95, NauseaFreeNow, SteveThurs and 35 others
Reply Quote Save Share Report
PeptideChemSF
Senior Member
1,890
9,012
Jan 2024
San Francisco, CA
May 23, 2026 at 10:09 PM#8
Dr.NateNeph said:
For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and…

Adding the part of the answer the thread has not reached. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.

Last edited: May 24, 2026 at 2:09 AM
37 7FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 34 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
Dr.CardioMD
VIP Member
2,678
14,567
Dec 2023
Cleveland, OH
May 24, 2026 at 1:30 AM#9

OP back with an update, since a thread like this is useless without one.

Six weeks on from posting: I stopped reading the weekly number and started reading a four-week average, and the "stall" I opened this thread about was a 1.8kg loss I could not see.

Last edited: May 24, 2026 at 7:30 AM
36 6roxy_nash, tony_orlando, Dr.NephBHM_UK and 33 others
Reply Quote Save Share Report
mike.trainer_LA
Senior Member
1,567
7,234
Apr 2024
Los Angeles, CA
May 24, 2026 at 5:37 PM#10
PeptideChemSF said:
Steady state is the thing most people miss.

That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.

36 11marcus_mpls, DeniseRN_TPA, SandraNC_45 and 33 others
Reply Quote Save Share Report

Similar Threads

SELECT trial: 20% MACE reduction — mechanistic deep dive7 replies
Semaglutide cardiovascular benefit independent of weight loss11 replies
STEP-HFpEF: semaglutide in heart failure with preserved EF15 replies
GLP-1 and arterial inflammation — hsCRP and IL-6 reduction data18 replies
Lp(a) on GLP-1 agonists — any impact on this risk factor?8 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register