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ForumsPublic SquareIs there a ceiling effect for GLP-1-mediated weight loss? — my results so far Page 5

Is there a ceiling effect for GLP-1-mediated weight loss? — my results so far

raj_cambridge Mon, Dec 15, 2025 at 6:20 AM 33 replies 1,411 viewsPage 5 of 7
Dr.PulmRoch
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Rochester, MN
Dec 19, 2025 at 11:20 AM#21
hank_denver said:
Keep the original post as written when you update it, and add the correction underneath.

Genuinely useful, thank you. I had the facts and not the framework. Taking it to my next appointment.

Last edited: Dec 19, 2025 at 12:20 PM
30 5rachel_ABQ, traveltech_sara, AttorneyGrant and 27 others
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Dr.AddMedPHL
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Mar 2024
Philadelphia, PA
Dec 20, 2025 at 5:55 PM#22

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Last edited: Dec 20, 2025 at 7:55 PM
29 4sarah_nash92, FitDadDave, RunnerRach and 26 others
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PurityPaulOR
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Dec 22, 2025 at 12:29 AM#23
Dr.AddMedPHL said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

This matches mine closely enough to be worth saying so out loud. I had assumed I was the exception until I read this.

28 3Admin, Dr.Martinez, mike_mod and 25 others
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greg_boulder
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Boulder, CO
Dec 23, 2025 at 7:02 AM#24
Dr.AddMedPHL said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at Dr.AddMedPHL’s question from a different direction. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

27 2patPC_UT, Dr.DermMIA, fiona_VT and 24 others
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dave_SLC
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Aug 2024
Salt Lake City, UT
Dec 24, 2025 at 1:35 PM#25

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Last edited: Dec 24, 2025 at 5:35 PM
26 1Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 23 others
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