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ForumsPublic SquareIs there a ceiling effect for GLP-1-mediated weight loss? — my results so far Page 7

Is there a ceiling effect for GLP-1-mediated weight loss? — my results so far

raj_cambridge Mon, Dec 15, 2025 at 6:20 AM 33 replies 1,411 viewsPage 7 of 7
mia_MS2
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Jan 1, 2026 at 4:21 AM#31
raj_cambridge said:
Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

Second this.

Last edited: Jan 1, 2026 at 7:21 AM
49 24ricardo_MIA, BrianDallas92, labquiet_amy and 46 others
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Jan 2, 2026 at 10:33 AM#32
raj_cambridge said:
Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

Coming at raj_cambridge’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

Last edited: Jan 2, 2026 at 2:33 PM
48 23SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 45 others
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hank_denver
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Jan 3, 2026 at 4:44 PM#33

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

47 22denise_HTX, raj_cambridge, ingrid_STO and 44 others
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Dr.BariatricHTX
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Jan 4, 2026 at 10:55 PM#34

One thing that is still open after raj_cambridge’s answer:

How long did you give it before you decided it was working?

Last edited: Jan 5, 2026 at 4:55 AM
46 21stefan_berlin, Dr.EM_Chicago, pete_RVA and 43 others
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pat_auckland
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Jan 6, 2026 at 5:05 AM#35
hank_denver said:
Say what you would expect to see if you were wrong, before you look.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

45 20dan_philly, MeganSA_TX, LarryQC_SD and 42 others
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