Is there a ceiling effect for GLP-1-mediated weight loss? — my results so far

traveltech_sara said:

Bayesian meta-analysis perspective on the trial evidence: traditional frequentist meta-analyses report point estimates and confidence intervals.

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

Ask again with the specifics and you will get a better answer than this one.

WendyG_ATL said:

Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational…

Bookmarking. The distinction being drawn above is the one nobody else makes.

traveltech_sara said:

Bayesian meta-analysis perspective on the trial evidence: traditional frequentist meta-analyses report point estimates and confidence intervals.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.