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ForumsCardiovascular OutcomesSOUL trial preliminary data — semaglutide in T2DM cardiovascular outcomes Page 4

SOUL trial preliminary data — semaglutide in T2DM cardiovascular outcomes

Dr.CardioMD Tue, Jun 2, 2026 at 1:06 AM 20 replies 546 viewsPage 4 of 4
rachel_ABQ
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Jun 5, 2026 at 10:54 PM#16
SarahChen_PharmD said:
Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my…

Mine went the same way, slower. I had assumed I was the exception until I read this.

Last edited: Jun 6, 2026 at 3:54 AM
47 22nick_newbie, DadBodDave, AmyNC_wife and 44 others
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AmyNC_wife
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Jun 6, 2026 at 1:51 PM#17
dan_philly said:
I want to bring up the cardiovascular angle on cardiovascular risk.

Metabolic syndrome resolution on cardiovascular risk: I went from meeting 4 of 5 diagnostic criteria to meeting ZERO after 12 months of treatment.

The 5 criteria (and my journey):

  1. Waist circumference: 51" → 37" ✅ Resolved
  2. Triglycerides: 259 → 109 ✅ Resolved
  3. HDL: 35 → 61 ✅ Resolved
  4. Blood pressure: 149/97 → 122/76 ✅ Resolved
  5. Fasting glucose: 124 → 87 ✅ Resolved

Metabolic syndrome reversal is, in my view, the most medically significant outcome of GLP-1 therapy.

46 21julia.endo, JessicaM_2024, TomFromTexas and 43 others
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Dr.GutHealth
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Jun 7, 2026 at 4:47 AM#18

The figures, for anyone assembling their own picture. For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and subcutaneous bioavailability near 89%. Those four numbers explain most of the questions people ask about timing.

45 20jennifer_SEA, tyler_CSCS, VanRx_Mike and 42 others
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ricardo_MIA
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Miami, FL
Jun 7, 2026 at 7:43 PM#19

One thing that is still open after dan_philly’s answer:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?

44 19KetoKyle, CanadaChris, ZaraB_AL and 41 others
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mike_mod
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Jun 8, 2026 at 10:39 AM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Thread quality here is what the rules are for. Keep it up.

22 22PurityPaulOR, MaxMetOK, MounjBrad and 19 others
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