Orforglipron Phase 3 ATTAIN-1 topline — anyone have experience?

lisa_labSD said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Coming at lisa_labSD’s question from a different direction. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

One thing that is still open after lisa_labSD’s answer:

How would you tell the difference between that and the alternative explanation?

jason_paloalto said:

Worth stating the units and the reference range whenever you post a number here.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

I would rather be corrected than agreed with, if it comes to it.

jason_paloalto said:

Worth stating the units and the reference range whenever you post a number here.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.