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ForumsOral GLP-1 AgonistsOrforglipron Phase 3 ATTAIN-1 topline — anyone have experience? Page 6

Orforglipron Phase 3 ATTAIN-1 topline — anyone have experience?

steve_okc Sat, Apr 26, 2025 at 11:16 AM 30 replies 1,800 viewsPage 6 of 6
Dr.NephBHM_UK
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May 12, 2025 at 10:23 AM#26
jason_paloalto said:
Worth stating the units and the reference range whenever you post a number here.

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

36 9Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 33 others
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Dr.LeslieOBGYN
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May 14, 2025 at 5:08 AM#27

Adding the clinical framing, because it changes how the question reads. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

37 10FranDenver, Dr.BariatricHTX, LindaRN_retired and 34 others
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NeuroNate
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May 15, 2025 at 11:54 PM#28
Dr.LeslieOBGYN said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Same pattern here, and in the same order.

38 11sarah_TO, wendy_avl, jason_paloalto and 35 others
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VendorMark
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May 17, 2025 at 6:41 PM#29
Dr.LeslieOBGYN said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

There is a second half to this that has not been said yet. The gap between trial results and real-world results is consistent and it is not fraud. Trial participants get titration by protocol, scheduled contact, free drug and dietetic support; removing that infrastructure costs a few percentage points every time it has been measured. When your own curve sits below the published mean, that is the likeliest explanation before anything about you or your material.

39 12Dr.PeteFamMed, claudia_zurich, nancy_portland and 36 others
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steve_okc
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May 19, 2025 at 1:29 PM#30

Reporting back.

Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

Last edited: May 19, 2025 at 5:29 PM
11 9KetoKyle, CanadaChris, ZaraB_AL and 8 others
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