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ForumsOral GLP-1 AgonistsOrforglipron Phase 3 ATTAIN-1 topline — anyone have experience? Page 3

Orforglipron Phase 3 ATTAIN-1 topline — anyone have experience?

steve_okc Sat, Apr 26, 2025 at 11:16 AM 30 replies 1,800 viewsPage 3 of 6
labquiet_amy
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Apr 28, 2025 at 7:13 PM#11
hyun_seoul said:
Relative and absolute effects need reading together.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Last edited: Apr 28, 2025 at 9:13 PM
50 23TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 47 others
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NurseAsh_DET
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Apr 29, 2025 at 6:33 AM#12
wendy_avl said:
The manufacturing argument is the underrated one.

Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.

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raj_cambridge
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Apr 29, 2025 at 5:54 PM#13
hyun_seoul said:
Relative and absolute effects need reading together.

This is where I part company with the consensus forming above. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

2 0TomTeleRx, DoseLogDan
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Dr.PathRoch
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Apr 30, 2025 at 5:15 AM#14

The figures, for anyone assembling their own picture. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

3 1SaraMom3, Dr.MetabolicMD, RetaRick_CA
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Admin
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Apr 30, 2025 at 4:36 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again.

4 2PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 1 other
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