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ForumsOral GLP-1 AgonistsHow far away are we really from an oral option — 12 month update Page 7

How far away are we really from an oral option — 12 month update

HPLC_Greg Wed, Jun 4, 2025 at 7:45 PM 47 replies 2,552 viewsPage 7 of 10
VendorMark
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Jun 12, 2025 at 5:28 AM#31

Adding the clinical framing, because it changes how the question reads. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Last edited: Jun 12, 2025 at 7:28 AM
34 7DebRD_ATL, KristenIndy, MarkLI_maint and 31 others
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Dr.PeteFamMed
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Jun 12, 2025 at 6:04 PM#32
VendorMark said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Mine went the same way, slower. The detail I would add is minor and it is already implied above.

35 8tommy_boulder, hyun_seoul, jim_asheville and 32 others
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rick_sfbay
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Jun 13, 2025 at 6:40 AM#33
VendorMark said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Coming at VendorMark’s question from a different direction. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

36 9james_edin, FranDenver, Dr.BariatricHTX and 33 others
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BiostatsBrad
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Jun 13, 2025 at 7:16 PM#34

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

37 10james_edin, FranDenver, Dr.BariatricHTX and 34 others
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DeniseRN_TPA
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Jun 14, 2025 at 7:51 AM#35

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

38 11Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 35 others
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