Has anyone dealt with oral glp-1 adherence?

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

carl_compliance said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Can confirm. Same sequence, different timescale. Nothing to add that would improve it.

carl_compliance said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Adding the part of the answer the thread has not reached. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

A narrower follow-up, since the general answer is now clear:

How long did you give it before you decided it was working?