sophie_paris said:The OASIS programme put 50mg oral in the same territory as 2.4mg injectable — around 15% mean weight loss — but it needed a dose 20 times larger to…
This answered a question I did not know how to ask. Sending this to two other people who asked me the same thing last week.
From the other side of the consultation, briefly. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.
anders_CPH said:The mechanism and the magnitude are separate questions.
Pushing back on anders_CPH here. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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View ResultsOne concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.