New Year goals check-in — looking for input

andrew_nyc said:

Alcohol relationship change with food noise: I used to drink 3-4 beers most nights.

The GLP-1 and alcohol use disorder connection, relevant to food noise: observational data from Scandinavian registries shows reduced alcohol-related hospitalizations in GLP-1 agonist users[1].

The mechanism is plausible: GLP-1R is expressed in the mesolimbic reward pathway (VTA, nucleus accumbens). Agonism at these receptors may reduce the reinforcing properties of alcohol, similar to the reduction in "food noise."

RCTs for GLP-1 agonists in AUD are now underway. If positive, this would be a paradigm-shifting repurposing of existing medications.

jennifer_SEA said:

"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants.

Saving this. It is the first explanation that did not require me to already understand it. Adding it to my notes with a link back to this thread.

andrew_nyc said:

Alcohol relationship change with food noise: I used to drink 3-4 beers most nights.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

I would rather be corrected than agreed with, if it comes to it.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.