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Evidence-based GLP-1 & peptide discussion since 2023
ForumsBuyer Beware⚠ Fake COAs — March 2026 Page 3

⚠ Fake COAs — March 2026

Dr.CardioMD Thu, Oct 31, 2024 at 8:56 AM 54 replies 3,020 viewsPage 3 of 11
FDA_TrackerJim
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Nov 1, 2024 at 7:53 PM#11
sophie_paris said:
Vendor quality matters when discussing certificates of analysis.

My HPLC chromatogram analysis for certificates of analysis — I sent my batch to Janoshik and here's what the results showed:

Main peak retention time: 16.8 minutes (consistent with semaglutide reference standard)
Peak purity: 99.8%
Related substances: 0.4% (single impurity at 10.3 minutes — likely a synthesis intermediate)
Mass spec: m/z 4113.5 (matches expected molecular weight)

This is a clean result. The mass spec confirmation is particularly important — it proves the molecule is actually semaglutide and not a substitution.

Last edited: Nov 1, 2024 at 10:53 PM
15 13Dr.Martinez, mike_mod, SarahChen_PharmD and 12 others
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nancy_portland
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Aug 2024
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Nov 2, 2024 at 8:47 AM#12
Dr.PainCLE said:
One addition: an unstated method makes a report close to uninterpretable.

Saving this. It is the first explanation that did not require me to already understand it.

16 14KristenIndy, MarkLI_maint, Dr.PeteFamMed and 13 others
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AmyNC_wife
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Nov 2, 2024 at 9:40 PM#13
sophie_paris said:
Vendor quality matters when discussing certificates of analysis.

I tested my certificates of analysis batch through Janoshik — 97.0% purity. That's within acceptable range for compounded peptides. Turnaround was 12 business days.

The test costs ~$135 but gives you actual HPLC chromatography data plus mass spec confirmation. For the peace of mind alone, it's worth every penny. I test every new batch from a new vendor.

17 15PharmD_Rodriguez, julia.endo, JessicaM_2024 and 14 others
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Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
BethLabQueen
Senior Member
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May 2024
Virginia
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Nov 3, 2024 at 10:33 AM#14
Dr.CardioMD said:
I have a certificate reporting 99.2% purity and 6.1mg content on a vial sold as 5mg, and I cannot work out whether those two numbers are consistent or…

Community-verified vendors for certificates of analysis: I maintain a spreadsheet of Janoshik-verified test results submitted by community members. Across 49 submitted tests:

  • 78% tested at ≥98% purity
  • 15% tested at 95-98% purity
  • 7% tested at <95% purity (concerning)

The vendors with consistently high purity results are listed in the Vendor Directory. We update monthly based on new community submissions.

Last edited: Nov 3, 2024 at 11:33 AM
18 16cory_ATX, lori_vegas, Dr.PulmRoch and 15 others
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mike_mod
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Nov 3, 2024 at 11:26 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.

19 17PurityPaulOR, MaxMetOK, MounjBrad and 16 others
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