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ForumsPharmacology & MechanismsGLP-1R desensitization — 12 month update Page 7

GLP-1R desensitization — 12 month update

WendyG_ATL Sat, Aug 16, 2025 at 8:18 AM 40 replies 1,750 viewsPage 7 of 8
raj_cambridge
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Aug 22, 2025 at 8:13 PM#31

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Happy to go further on any of that.

Last edited: Aug 22, 2025 at 9:13 PM
47 20SleepFixSam, PurityPaulOR, MaxMetOK and 44 others
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NurseAsh_DET
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Aug 23, 2025 at 5:25 AM#32

A narrower follow-up, since the general answer is now clear:

How would you tell the difference between that and the alternative explanation?

48 21ricardo_MIA, BrianDallas92, labquiet_amy and 45 others
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RetaRick_CA
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Aug 23, 2025 at 2:37 PM#33
raj_cambridge said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

I read this differently from raj_cambridge, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

49 22DadBodDave, AmyNC_wife, SkepticalSean and 46 others
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greg_boulder
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Aug 23, 2025 at 11:48 PM#34
raj_cambridge said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

Ask again with the specifics and you will get a better answer than this one.

Last edited: Aug 24, 2025 at 1:48 AM
50 23patPC_UT, Dr.DermMIA, fiona_VT and 47 others
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Dr.EndoEP
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Aug 24, 2025 at 8:59 AM#35
raj_cambridge said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

That reframing is the part I needed.

1 24LindaRN_retired
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