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ForumsPharmacology & MechanismsGLP-1R desensitization — 12 month update Page 3

GLP-1R desensitization — 12 month update

WendyG_ATL Sat, Aug 16, 2025 at 8:18 AM 40 replies 1,750 viewsPage 3 of 8
CarlaRPh_TPA
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Aug 17, 2025 at 5:31 PM#11
Dr.PeteFamMed said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.

35 8FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 32 others
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Dr.NephBHM_UK
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Aug 17, 2025 at 8:30 PM#12
carl_compliance said:
The pharmacokinetics explain nearly every practical question asked here.

Saving this. It is the first explanation that did not require me to already understand it. Sending this to two other people who asked me the same thing last week.

Last edited: Aug 18, 2025 at 2:30 AM
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Dr.RaviCardio
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Aug 17, 2025 at 11:29 PM#13
Dr.PeteFamMed said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

This is where I part company with the consensus forming above. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

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Dr.NateNeph
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Aug 18, 2025 at 2:28 AM#14

The figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: Aug 18, 2025 at 4:28 AM
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mike_mod
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Aug 18, 2025 at 5:27 AM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.

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