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ForumsDosing & ProtocolsSteady-state concentrations across dose tiers — anyone have experience? Page 7

Steady-state concentrations across dose tiers — anyone have experience?

Dr.ReproEndo Thu, Sep 18, 2025 at 2:39 PM 47 replies 1,788 viewsPage 7 of 10
NurseKim_ATL
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Sep 30, 2025 at 10:24 AM#31

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

38 13denise_HTX, raj_cambridge, ingrid_STO and 35 others
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newstart_MO
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Feb 2026
Springfield, MO
Oct 1, 2025 at 7:09 AM#32
NurseKim_ATL said:
It is worth asking what the claim would look like if it were false.

Same experience, arrived at from the opposite direction. Posting only so the count is not one.

Last edited: Oct 1, 2025 at 1:09 PM
37 12LibrarianMeg, bri_stats, pete_manc_UK and 34 others
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MeganSA_TX
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Oct 2, 2025 at 3:53 AM#33
NurseKim_ATL said:
It is worth asking what the claim would look like if it were false.

There is a second half to this that has not been said yet. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

I would rather be corrected than agreed with, if it comes to it.

36 11JessicaM_2024, TomFromTexas, mike.trainer_LA and 33 others
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PharmacoVig_BOS
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Oct 3, 2025 at 12:37 AM#34

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

35 10kate.chem, DataDave, Dr.GutHealth and 32 others
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SaraMom3
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Aug 2024
Ohio
Oct 3, 2025 at 9:20 PM#35

One thing that is still open after NurseKim_ATL’s answer:

What would you measure differently if you were starting again?

Last edited: Oct 4, 2025 at 1:20 AM
34 9ZaraB_AL, JakeSmashed95, NauseaFreeNow and 31 others
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