Creatine loading vs maintenance on GLP-1 — my results so far

anders_CPH said:

DerekSJ_a1c said: ...I stopped maintenance dosing and regained all the weight...

This is my experience too, for whatever a second data point is worth. The detail I would add is minor and it is already implied above.

Dr.RaviCardio said:

Maintenance phase reality on maintenance dosing: reached my goal 8 months ago and now I'm in maintenance.

Dr.RaviCardio said:

...the STEP extension data on maintenance dosing is concerning...

Let me offer a different interpretation of the same data. Yes, 2/3 of weight was regained after discontinuation. But consider:

• This is consistent with EVERY chronic disease medication ever studied
• 1/3 of patients maintained significant weight loss — who are they and why?
• The metabolic improvements partially persisted even with weight regain
• The data supports long-term treatment, not a "course" of therapy

The takeaway isn't "the drug fails when you stop" — it's "chronic diseases require ongoing treatment." We've always known this.

Dr.RaviCardio said:

Maintenance phase reality on maintenance dosing: reached my goal 8 months ago and now I'm in maintenance.

Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.

Adding the clinical framing, because it changes how the question reads.

Pregnancy after maintenance dosing weight loss: stopped GLP-1 medication 4 months before TTC as recommended. Was terrified of regaining weight during pregnancy.

Worked closely with my OB and MFM. Gained 27 lbs during pregnancy (within recommended range). Baby is healthy. The metabolic improvements from pre-pregnancy weight loss gave both of us a healthier pregnancy.

If you're planning pregnancy, discuss the medication discontinuation timeline with your OB. GLP-1 agonists are NOT safe during pregnancy.

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