🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSemaglutide (Ozempic / Wegovy)Has anyone dealt with okay who else cannot stop burping?

Has anyone dealt with okay who else cannot stop burping?

LeilaHI Thu, Feb 22, 2024 at 7:58 AM 15 replies 2,173 viewsPage 1 of 3
This thread is more than 27 months old. Information may be outdated. Consider searching for more recent discussions.
LeilaHI
Member
167
789
Jan 2025
Honolulu, HI
Feb 22, 2024 at 7:58 AM#1

I have been on semaglutide for nine months, currently holding 1.7mg rather than pushing to 2.4mg, and the last two dose steps bought me much less than the first two did.

The question I want answered is whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg.

Numbers rather than impressions, if you have them.

46 16COA_Karl, MikeFit_NJ, InsuranceTom and 43 others
Reply Quote Save Share Report
DanielChem_CHI
Senior Member
1,234
5,678
Mar 2024
Chicago, IL
Feb 22, 2024 at 8:09 AM#2

Answering the narrow version, because the broad one does not have a single answer. The dose-response is real but shallow at the top. Across STEP 1 and STEP 4 the gap between 1.7mg and 2.4mg is a couple of percentage points of body weight on average, and the average is carrying a wide spread — plenty of people at 1.7mg sit above the 2.4mg mean. If a dose is working and tolerable, "working" is the relevant variable, not "maximal".

Correct me if the detail matters more than I have assumed.

Last edited: Feb 22, 2024 at 10:09 AM
45 15Dr.DermMIA, fiona_VT, denise_HTX and 42 others
Reply Quote Save Share Report
tommy_boulder
Member
234
1,123
Nov 2024
Boulder, CO
Feb 22, 2024 at 8:20 AM#3
DanielChem_CHI said:
The dose-response is real but shallow at the top.

That is correct as far as it goes, and here is where it stops going. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.

44 14robert_kc, dan_philly, MeganSA_TX and 41 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
maya_sedona
Member
289
1,234
Sep 2024
Sedona, AZ
Feb 22, 2024 at 8:31 AM#4
LeilaHI said:
I have been on semaglutide for nine months, currently holding 1.7mg rather than pushing to 2.4mg, and the last two dose steps bought me much less than…

That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.

I would rather be corrected than agreed with, if it comes to it.

43 13MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 40 others
Reply Quote Save Share Report
NurseLeah_Nash
Member
278
1,234
Sep 2024
Nashville, TN
Feb 22, 2024 at 9:29 AM#5

Adding the clinical framing, because it changes how the question reads.

LeilaHI said:
...but the FDA says semaglutide...

Interesting point. I want to add some regulatory nuance: the FDA labeling reflects the specific clinical trial data submitted for approval. Real-world clinical practice often extends beyond the FDA label based on emerging evidence and clinical judgment.

Example: semaglutide was first approved for diabetes (Ozempic), then obesity (Wegovy). The molecule didn't change — our understanding of its applications expanded. Similarly, semaglutide may evolve as more data accumulates.

Last edited: Feb 22, 2024 at 10:29 AM
42 12Dr.NateNeph, PharmD_Rodriguez, julia.endo and 39 others
Reply Quote Save Share Report

Similar Threads

STEP 1-5 trials comprehensive summary — efficacy endpoints compiled12 replies
Oral semaglutide 50mg Phase 3 — OASIS program results16 replies
Semaglutide pharmacokinetics — half-life, Tmax, steady state modeling10 replies
Compounded semaglutide stability data — temperature and light sensitivity16 replies
0.25mg → 2.4mg titration: optimal schedule based on clinical data6 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register