Has anyone dealt with okay who else cannot stop burping?

Dr.PulmRoch said:

If two explanations both fit, the useful question is which one predicts something the other does not.

All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

tommy_boulder said:

Steady state is the thing most people miss.

Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.

Dr.PulmRoch said:

If two explanations both fit, the useful question is which one predicts something the other does not.

This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.