Semaglutide cardiovascular benefit: SELECT trial deep dive — looking for input

labquiet_amy said:

I want to bring up the cardiovascular angle on cardiovascular risk.

Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my key markers:

Weight: consistent downtrend, -2.1 lbs/week average
Fasting glucose (finger stick): stable at 88 mg/dL
Blood pressure (home): 116/74 average
Resting heart rate: 68 bpm (down from 84)
Waist circumference: down 18 inches total

The resting heart rate improvement correlates with cardiovascular fitness gains. Everything is moving in the right direction.

labquiet_amy said:

I want to bring up the cardiovascular angle on cardiovascular risk.

labquiet_amy said:

...cardiovascular risk is just another fad...

I understand the skepticism — we've all seen "miracle" weight loss solutions come and go. But consider what makes GLP-1 agonists different:

• Phase 3 RCTs with thousands of participants (not 20-person pilot studies)
• Published in NEJM, JAMA, Lancet (not press releases)
• Replicated across multiple independent research groups
• Proven cardiovascular and renal benefits beyond weight loss
• Biological mechanism fully characterized at the receptor level

This isn't a fad — it's a new drug class supported by the highest level of clinical evidence. The comparison to past fads is understandable but inappropriate.

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Carry on.

Clinical perspective, offered as context rather than as advice.

Senior perspective on cardiovascular risk: I'm 70 years old and started this journey skeptically. My cardiologist recommended it after years of failed interventions.

14 months later: down 58 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.

To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.

TinaHashiRN said:

Senior perspective on cardiovascular risk: I'm 70 years old and started this journey skeptically.

Adding a me-too, because a thread of one person's experience is not much use. I had assumed I was the exception until I read this.