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ForumsSemaglutide (Ozempic / Wegovy)Semaglutide cardiovascular benefit: SELECT trial deep dive — looking for input Page 12

Semaglutide cardiovascular benefit: SELECT trial deep dive — looking for input

MaxMetOK Tue, Dec 17, 2024 at 2:04 PM 56 replies 2,950 viewsPage 12 of 12
jim_asheville
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Feb 9, 2025 at 9:52 PM#56

One thing that is still open after SleepDoc_PDX’s answer:

What did you change at the same time, and can you separate the two now?

Last edited: Feb 10, 2025 at 12:52 AM
10 8MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 7 others
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Dr.EndoIndy
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Feb 11, 2025 at 4:39 AM#57
wendy_avl said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Pushing back on wendy_avl here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

11 9LeilaHI, marcus_mpls, DeniseRN_TPA and 8 others
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BariatricNurseD
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Feb 12, 2025 at 11:25 AM#58
wendy_avl said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

That is the short version; the long version is somebody else's post.

12 10josh_phd_bmore, roxy_nash, tony_orlando and 9 others
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oliver_london
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Feb 13, 2025 at 6:10 PM#59
wendy_avl said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

13 11jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 10 others
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PedsEndoPhilly
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Feb 15, 2025 at 12:55 AM#60

Clinical perspective, offered as context rather than as advice. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Last edited: Feb 15, 2025 at 5:55 AM
35 8MikeNYC_runner and 32 others
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