Semaglutide cardiovascular benefit: SELECT trial deep dive — looking for input

PeptideSynthNJ said:

Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 →…

Cardiac biomarkers and cardiovascular risk: my cardiologist ordered advanced cardiac labs given my family history. Results were encouraging:

• NT-proBNP: 55 pg/mL (normal, cardiac function preserved)
• Lp(a): 25 nmol/L (genetic, unchanged — expected)
• ApoB: dropped from 150 to 95 mg/dL (excellent response)
• Coronary calcium score: 0 (unchanged from baseline — reassuring)

The ApoB reduction is particularly meaningful — it's considered the best single predictor of cardiovascular risk. GLP-1 therapy seems to improve this consistently.

PeptideSynthNJ said:

Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 →…

That reframing is the part I needed.

Adding the clinical framing, because it changes how the question reads.

Metabolic syndrome resolution on cardiovascular risk: I went from meeting 5 of 5 diagnostic criteria to meeting ZERO after 10 months of treatment.

The 5 criteria (and my journey):

1. Waist circumference: 49" → 37" ✅ Resolved
2. Triglycerides: 263 → 113 ✅ Resolved
3. HDL: 33 → 55 ✅ Resolved
4. Blood pressure: 143/93 → 121/75 ✅ Resolved
5. Fasting glucose: 128 → 85 ✅ Resolved

Metabolic syndrome reversal is, in my view, the most medically significant outcome of GLP-1 therapy.

Dr.LeslieOBGYN said:

Metabolic syndrome resolution on cardiovascular risk: I went from meeting 5 of 5 diagnostic criteria to meeting ZERO after 10 months of treatment.

This is my experience too, for whatever a second data point is worth.

OP back with an update, since a thread like this is useless without one.

Update since I posted: I held at 1.7mg for a further twelve weeks and lost another 4kg slowly, which settles it for me. I was escalating because the number was available, not because I had stopped responding.