5-Amino-1MQ — 12 month update

One thing that is still open after sarah_TO’s answer:

Was that from a primary source or from a summary of one?

Dr.ObesityLA said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Dr.ObesityLA said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

Dr.ObesityLA said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

That reframing is the part I needed. Printing the relevant bit and taking it with me.

Adding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.