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ForumsMASH / Liver DiseaseHas anyone dealt with de novo lipogenesis reduction on glp-1? Page 6

Has anyone dealt with de novo lipogenesis reduction on glp-1?

NurseLeah_Nash Tue, Nov 18, 2025 at 1:33 AM 34 replies 1,698 viewsPage 6 of 7
Dr.PeteFamMed
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Nov 26, 2025 at 10:38 AM#26

Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

1 24hyun_seoul
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patPC_UT
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Nov 26, 2025 at 7:11 PM#27
Dr.PeteFamMed said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Same pattern here, and in the same order. Nothing to add that would improve it.

2 0mike.trainer_LA, sarah_nash92
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Dr.EndoEP
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Nov 27, 2025 at 3:44 AM#28
Dr.PeteFamMed said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

There is a second half to this that has not been said yet. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

Last edited: Nov 27, 2025 at 5:44 AM
3 1FranDenver, Dr.BariatricHTX, LindaRN_retired
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bri_stats
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Nov 27, 2025 at 12:17 PM#29

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

Last edited: Nov 27, 2025 at 4:17 PM
4 2JessicaM_2024, TomFromTexas, mike.trainer_LA and 1 other
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NurseLeah_Nash
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Nov 27, 2025 at 8:50 PM#30

Closing the loop on my own question.

Coming back a few months on. It held. Nothing dramatic to report, which is the report.

26 24Dr.NateNeph, PharmD_Rodriguez, julia.endo and 23 others
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