Creatine kinase elevations on GLP-1 — what worked for you?

One thing that is still open after andrew_nyc’s answer:

What did you change at the same time, and can you separate the two now?

JakeBK_lifts said:

Physical therapist weighing in on lean mass.

DEXA scan update relevant to lean mass:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.4g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.

JakeBK_lifts said:

Physical therapist weighing in on lean mass.

My endo's protocol for lean mass plateau: if weight loss stalls for 6+ weeks at current dose, we go through this checklist before titrating up:

1. Food diary review — is intake creeping up?
2. Protein check — minimum 100g/day
3. Activity audit — steps + resistance training
4. Sleep quality — poor sleep kills GLP-1 efficacy
5. Stress/cortisol management

Only after addressing all of these do we increase the dose. Often fixing one lifestyle factor restarts progress without needing more medication.

JakeBK_lifts said:

Physical therapist weighing in on lean mass.

Genuinely useful, thank you. I had the facts and not the framework.

From the other side of the consultation, briefly. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.