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ForumsMASH / Liver DiseaseDe novo lipogenesis reduction on GLP-1 — mechanistic hepatology Page 3

De novo lipogenesis reduction on GLP-1 — mechanistic hepatology

MASHdoc_SA Mon, Jun 1, 2026 at 1:48 AM 17 replies 523 viewsPage 3 of 4
mona_PHX
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Jun 2, 2026 at 5:10 AM#11
Dr.KarenChen said:
Liver ultrasound comparison for liver and MASH: my hepatologist ordered serial ultrasounds to track NAFLD regression.

Saving this. It is the first explanation that did not require me to already understand it.

3 1RetaRick_CA, JenPlateau, SallyK_inj
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claudia_zurich
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Jun 2, 2026 at 9:15 AM#12

From the other side of the consultation, briefly. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Last edited: Jun 2, 2026 at 3:15 PM
4 2tammy_FL, Dr.LipidDallas, alex_tucson and 1 other
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Dr.PainCLE
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Jun 2, 2026 at 1:20 PM#13
Dr.ObesityMed said:
Liver imaging follow-up for liver and MASH: FibroScan at baseline showed CAP score 315 dB/m (moderate steatosis) and stiffness 8.8 kPa (possible…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

That is the short version; the long version is somebody else's post.

Last edited: Jun 2, 2026 at 4:20 PM
5 3oliver_london, tane_welly, Dr.PathRoch and 2 others
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raj_cambridge
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Jun 2, 2026 at 5:25 PM#14

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

6 4PharmHunterJen, TomTeleRx, DoseLogDan and 3 others
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Admin
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Jun 2, 2026 at 9:29 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

7 5PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 4 others
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