🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionResistance training prevents 73% lean mass loss on semaglutide — RCT review Page 3

Resistance training prevents 73% lean mass loss on semaglutide — RCT review

MikeFit_NJ Mon, Jun 8, 2026 at 6:43 AM 11 replies 220 viewsPage 3 of 3
nick_newbie
New Member
18
56
Jun 2026
Virginia
Online
Jun 8, 2026 at 1:18 PM#11
Dr.SurgeonPGH said:
The honest range is roughly 20 to 40% of total loss as lean mass without deliberate resistance training, and roughly 10 to 20% with it plus adequate…

Genuinely useful, thank you. I had the facts and not the framework. Taking it to my next appointment.

29 2robert_kc, dan_philly, MeganSA_TX and 26 others
Reply Quote Save Share Report
pete_nash
Member
312
1,345
Aug 2024
Nashville, TN
Jun 8, 2026 at 3:37 PM#12

Clinical perspective, offered as context rather than as advice.

DEXA scan update relevant to lean mass:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass284 lbs214 lbs211 lbs
Fat mass114 lbs84 lbs46 lbs
Lean mass152 lbs151 lbs158 lbs
Body fat %45%31%25%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.5g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.

Last edited: Jun 8, 2026 at 9:37 PM
30 3Dr.Martinez, mike_mod, SarahChen_PharmD and 27 others
Reply Quote Save Share Report
KevinCompounds
VIP Member
5,432
18,234
Dec 2023
Nevada
Jun 8, 2026 at 5:57 PM#13
Dr.ObesityLA said:
Training does two things here and only one of them is on the scale.

Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months):

MetricBaselineMonth 3Month 6Month 9
Skeletal Muscle (lbs)76706974
Body Fat (lbs)93785644
Body Fat %42%34%25%21%
Visceral Fat (cm²)1731189363

Note: skeletal muscle mass dipped initially then recovered with consistent resistance training + high protein. The visceral fat reduction is where the metabolic magic happens.

31 4MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 28 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
Dr.GutHealth
Senior Member
1,456
7,890
Mar 2024
Minnesota
Jun 8, 2026 at 8:17 PM#14
MikeFit_NJ said:
There is also a quality change that the scan cannot see.
MikeFit_NJ said:
...the muscle loss concern with lean mass...

This is a legitimate and well-studied concern. Let me put some numbers on it:

In STEP 1, approximately 39% of weight lost was lean mass. However, the Lundgren 2024 study showed that structured resistance training reduced this to ~25% lean mass loss.

Context matters: at BMI 35+, you're carrying excess lean mass to support the extra weight. Losing some lean mass is expected and not inherently harmful if you maintain adequate muscle function through exercise.

The solution isn't avoiding the medication — it's combining it with proper exercise and protein intake.

32 5Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 29 others
Reply Quote Save Share Report
Admin
Administrator
2,456
9,812
Oct 2023
Online
Jun 8, 2026 at 10:37 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.

33 6PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 30 others
Reply Quote Save Share Report

Similar Threads

DEXA scan longitudinal data — 12 months on GLP-1 + lifting18 replies
Zone 2 cardio + GLP-1: synergistic metabolic benefits — evidence18 replies
Creatine kinase elevations on GLP-1 — exercise-induced or concerning?14 replies
Body recomposition protocol: GLP-1 + progressive overload + high protein8 replies
Walking 10,000 steps/day impact on GLP-1 weight loss — pedometer study6 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register