Oral semaglutide 50mg Phase 3 — OASIS program results

Dr.ObesityMed said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.

Dr.RaviCardio said:

Worth stating the units and the reference range whenever you post a number here.

Coming at Dr.RaviCardio’s question from a different direction. The dose-response is real but shallow at the top. Across STEP 1 and STEP 4 the gap between 1.7mg and 2.4mg is a couple of percentage points of body weight on average, and the average is carrying a wide spread — plenty of people at 1.7mg sit above the 2.4mg mean. If a dose is working and tolerable, "working" is the relevant variable, not "maximal".

The figures, for anyone assembling their own picture. Worth knowing that the injection site changes very little. Abdomen, thigh and upper arm are bioequivalent for semaglutide, so a site change is not a plausible explanation for a bad week.

A narrower follow-up, since the general answer is now clear:

What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.