Has anyone dealt with coronary artery calcium score changes on glp-1?

KarenAZ_mom said:

My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.

Metabolic syndrome resolution on cardiovascular risk: I went from meeting 5 of 5 diagnostic criteria to meeting ZERO after 10 months of treatment.

The 5 criteria (and my journey):

1. Waist circumference: 49" → 35" ✅ Resolved
2. Triglycerides: 221 → 106 ✅ Resolved
3. HDL: 33 → 53 ✅ Resolved
4. Blood pressure: 141/91 → 119/73 ✅ Resolved
5. Fasting glucose: 116 → 85 ✅ Resolved

Metabolic syndrome reversal is, in my view, the most medically significant outcome of GLP-1 therapy.

mike_nyc said:

Metabolic syndrome resolution on cardiovascular risk: I went from meeting 5 of 5 diagnostic criteria to meeting ZERO after 10 months of treatment.

mike_nyc said:

...we're creating a generation dependent on cardiovascular risk...

I understand the concern, but consider this analogy: are we "creating a generation dependent on" blood pressure medication? Cholesterol medication? Thyroid medication?

Obesity is a chronic disease with biological drivers. Treating it with medication is no different from treating any other chronic condition. The "dependency" framing implies weakness or moral failure — neither of which is accurate.

If ongoing medication is what keeps someone healthy, that's successful treatment, not dependency.

KarenAZ_mom said:

My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.

This is my experience too, for whatever a second data point is worth. I had assumed I was the exception until I read this.

Clinical perspective, offered as context rather than as advice.

6 month update on cardiovascular risk: down 60 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.