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ForumsCardiovascular OutcomesSOUL trial preliminary data — what worked for you? Page 3

SOUL trial preliminary data — what worked for you?

Dr.KarenChen Thu, May 16, 2024 at 2:46 PM 13 replies 2,080 viewsPage 3 of 3
Dr.ObesityMed
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May 21, 2024 at 4:05 AM#11
TrialNerd_Beth said:
BethLabQueen said: ...regarding the trial evidence...

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

11 9EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 8 others
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JenPlateau
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May 23, 2024 at 9:31 PM#12
mike_mod said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

This answered a question I did not know how to ask. Taking it to my next appointment.

12 10TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 9 others
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emma_london
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May 26, 2024 at 2:58 PM#13
TrialNerd_Beth said:
BethLabQueen said: ...regarding the trial evidence...

This is where I part company with the consensus forming above. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

13 11TomFromTexas, mike.trainer_LA, sarah_nash92 and 10 others
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Dr.RaviCardio
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May 29, 2024 at 8:27 AM#14

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: May 29, 2024 at 9:27 AM
14 12hans_munich, jason_sac26, chris_chi24 and 11 others
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mike_mod
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Jun 1, 2024 at 1:57 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

Last edited: Jun 1, 2024 at 3:57 AM
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